Article

Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer

2023-05-06

Abstract excerpt

<h4>Background: </h4> Men with incurable castration resistant prostate cancer (CRPC) are typically treated with taxanes; however, drug resistance rapidly develops. Thus, overcoming taxane resistant PC is a major clinical need. We previously identified a seven gene network in aggressive CRPC, which includes the mitotic serine threonine kinase BUB1 , a major regulator of the spindle assembly checkpoint (SAC). Alter...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 453eb309-b014-521a-88f3-4fce6b6095a3
DOI: 10.1101/2023.05.05.539598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancerDOI 10.1101/2023.05.05.539598Read

BUB1B MITOTIC KINASE DRIVES THERAPY RESISTANT PROSTATE CANCERSemantic proximity Read

Resistance to BET Inhibitor Leads to Alternative Therapeutic Vulnerabilities in Castration-Resistant Prostate CancerSemantic proximity Read

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategiesSemantic proximity Read

Exploiting Epigenetic Targets to Overcome Taxane Resistance in Prostate CancerSemantic proximity Read

Exploiting epigenetic targets to overcome taxane resistance in prostate cancerSemantic proximity Read

Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer.Semantic proximity Read

Expression of the checkpoint kinase BUB1 is a predictor of response to cancer therapiesSemantic proximity Read

Identification of genes required for enzalutamide resistance in castration-resistant prostate cancer cells <i>in vitro</i>Semantic proximity Read

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancerSemantic proximity Read

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6Semantic proximity Read

Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistanceSemantic proximity Read

Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancerSemantic proximity Read