Article

Exploiting Epigenetic Targets to Overcome Taxane Resistance in Prostate Cancer

2023-08-14

Abstract excerpt

The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival. To uncover novel targets, we performed an epigenetic drug screen on taxane (docetaxel and cabazitaxel) resistant CR-PCa cells. We identified BRPF reader proteins, along with several epigenetic groups (CBP/p300, Menin-MLL, PRMT5 and SI...

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Literature Corpus work: a978268e-282b-5511-937d-7cce71601023
DOI: 10.1101/2023.08.10.552560

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