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Article

Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance

13 Oct 2014

Abstract excerpt

BACKGROUND: Taxanes such as paclitaxel and docetaxel are used successfully to treat breast cancer, usually in combination with other agents. They interfere with microtubules causing cell cycle arrest; however, the mechanisms underlying the clinical effects of taxanes are yet to be fully elucidated. METHODS: Isogenic paclitaxel resistant (PACR) MDA‒MB‒231, paclitaxel resistant ZR75‒1 and docetaxel resistant (DOCR)...

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PMID: 25312014
DOI: 10.1186/1471-2407-14-762

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