Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Abstract excerpt

Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ovarian cancer diagnosis and treatment
• Share to 14-3-3 protein interactions
• Share to Microtubule and mitosis dynamics