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Article

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6

29 Nov 2016

Abstract excerpt

In prostate cancer, the development of castration resistance is pivotal in progression to aggressive disease. However, understanding of the pathways involved remains incomplete. In this study, we performed a high-throughput genetic screen to identify kinases that enable tumor formation by androgen-dependent prostate epithelial (LHSR-AR) cells under androgen-deprived conditions. In addition to the identification...

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PMID: 27899381
DOI: 10.1158/0008-5472.can-16-0455

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