Article

BUB1B MITOTIC KINASE DRIVES THERAPY RESISTANT PROSTATE CANCER

2025-11-10

Abstract excerpt

Castration-resistant prostate cancer (CRPC) that progresses despite treatment with potent AR antagonists such as enzalutamide is a major clinical problem. Through an unbiased systems biology approach, we previously identified a therapeutically relevant seven gene set that drives CRPC. The mitotic checkpoint kinase, BUB1B (BUBR1) is a key member of this gene set, and we report here that BUB1B is a tractable and pro...

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Literature Corpus work: 5046fb8b-96b9-53ca-bc2f-2060d853ab96
DOI: 10.1101/2025.11.09.687448

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