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Article

Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer

1 Feb 2023

Abstract excerpt

Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal PCa. Through genomic and transcriptomic analysis of patient datasets, we find that castration and chemotherapy-resistant tumors display the highest CIN and mitotic kinase levels....

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PMID: 36787737
DOI: 10.1016/j.xcrm.2023.100937

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