Article

Identification of genes required for enzalutamide resistance in castration-resistant prostate cancer cells <i>in vitro</i>

2020-03-27

Abstract excerpt

Castration-resistant prostate cancer can be treated with the anti-androgen enzalutamide, but responses and duration of response are variable. To identify genes that support enzalutamide resistance, we performed a short hairpin RNA (shRNA) screen in the bone-homing, castration-resistant prostate cancer cell line, C4-2B. We identified eleven genes ( TFAP2C, CAD, SPDEF, EIF6, GABRG2, CDC37, PSMD12, COL5A2, AR, MAP3K...

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Literature Corpus work: 33d18e9c-0c89-5b56-ba63-6737b9ea97e8
DOI: 10.1101/2020.03.27.011825

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