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Article

Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk.

The Biochemical journal - 21 Feb 2024

Sharma Pallavi Kaila, Weng Jui-Hung, Manschwetus Jascha T, Wu Jian, Ma Wen, Herberg Friedrich W, Taylor Susan S

Abstract excerpt

Leucine-rich repeat protein kinase 2 (LRRK2) is a multi-domain protein encompassing two of biology's most critical molecular switches, a kinase and a GTPase, and mutations in LRRK2 are key players in the pathogenesis of Parkinson's disease (PD). The availability of multiple structures (full-length and truncated) has opened doors to explore intra-domain cross-talk in LRRK2. A helix extending from the WD40 domain...

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Identifiers

PMID: 38305364
DOI: 10.1042/BCJ20230477
PMCID: PMC10903466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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