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Article

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

30 Jul 2018

Abstract excerpt

Current efforts to develop Zika virus (ZIKV) subunit vaccines have been focused on pre-membrane (prM) and envelope (E) proteins, but the role of NS1 in ZIKV-specific immune response and protection is poorly understood. Here, we develop an attenuated recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing ZIKV prM-E-NS1 as a polyprotein. This vectored vaccine candidate is attenuated in mice, where a...

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PMID: 30076287
DOI: 10.1038/s41467-018-05276-4

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