Article

Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge

2020-07-10

Abstract excerpt

Zika virus (ZIKV) envelope (E) protein is the major target of neutralizing antibodies in infected host, and thus represents a candidate of interest for vaccine design. However, a major concern in the development of vaccines against ZIKV and the related dengue virus is the induction of cross-reactive poorly neutralizing antibodies that can cause antibody-dependent enhancement (ADE) of infection. This risk necessita...

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Identifiers and source

Literature Corpus work: c2620db3-d812-5e72-8814-743f68709746
DOI: 10.1101/2020.07.09.196626

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