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Article

Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy

13 Jun 2019

Abstract excerpt

Viral subunit vaccines generally show low efficacy. In this study, we revealed an intrinsic limitation of subunit vaccine designs: artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine efficacy. More specifically, we identified an epitope on Zika virus (ZIKV) envelope protein domain III (EDIII) that is buried in the full-length envelope protein but becomes exposed in...

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PMID: 31189716
DOI: 10.1128/jvi.02187-18

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