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Article

Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.

Nature communications - 18 Jan 2022

Shen Jiangchuan, Zhao Yiling, Pham Nhung Tuyet, Li Yuxi, Zhang Yixiang, Trinidad Jonathan, Ira Grzegorz, Qi Zhi, Niu Hengyao

Abstract excerpt

Single-stranded DNA (ssDNA) commonly occurs as intermediates in DNA metabolic pathways. The ssDNA binding protein, RPA, not only protects the integrity of ssDNA, but also directs the downstream factor that signals or repairs the ssDNA intermediate. However, it remains unclear how these enzymes/factors outcompete RPA to access ssDNA. Using the budding yeast Saccharomyces cerevisiae as a model system, we find that...

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Identifiers

PMID: 35042867
DOI: 10.1038/s41467-021-27940-y
PMCID: PMC8766458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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