Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic binding of replication protein a is required for DNA repair.

Nucleic acids research - 8 Jul 2016

Chen Ran, Subramanyam Shyamal, Elcock Adrian H, Spies Maria, Wold Marc S

Abstract excerpt

Replication protein A (RPA), the major eukaryotic single-stranded DNA (ssDNA) binding protein, is essential for replication, repair and recombination. High-affinity ssDNA-binding by RPA depends on two DNA binding domains in the large subunit of RPA. Mutation of the evolutionarily conserved aromatic residues in these two domains results in a separation-of-function phenotype: aromatic residue mutants support DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Single-Stranded
Share to Molecular Dynamics Simulation
Share to Nucleic Acid Denaturation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Domains and Motifs

Share to Rad51 Recombinase

Share to Replication Protein A

Share to Single Molecule Imaging

Share to Video Recording

Source

Open in PubMed Open full text

Identifiers

PMID: 27131385
DOI: 10.1093/nar/gkw339
PMCID: PMC4937323

Genes

RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic binding of replication protein a is required for DNA repair.PMID 27131385Read ↗

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Semantic proximity Read ↗

Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints.Semantic proximity Read ↗

Replication Protein A, the Main Eukaryotic Single-Stranded DNA Binding Protein, a Focal Point in Cellular DNA MetabolismSemantic proximity Read ↗

Fluorescent human RPA to track assembly dynamics on DNASemantic proximity Read ↗

Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler.Semantic proximity Read ↗

Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA binding.Semantic proximity Read ↗

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein ASemantic proximity Read ↗

Theoretical prediction of the binding free energy for mutants of replication protein A.Semantic proximity Read ↗

The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break RepairSemantic proximity Read ↗

Actin nucleation safeguards single-stranded DNA and promotes replication fork protectionSemantic proximity Read ↗

Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.Semantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.