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Article

Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler.

Biochemistry - 17 Jul 2007

Cai Lifeng, Roginskaya Marina, Qu Youxing, Yang Zhengguan, Xu Ying, Zou Yue

Abstract excerpt

Human replication protein A (RPA), a heterotrimer composed of RPA70, RPA32, and RPA14 subunits, contains four single-stranded DNA (ssDNA) binding domains (DBD): DBD-A, DBD-B, and DBD-C in RPA70 and DBD-D in RPA32. Although crystallographic or NMR structures of these DBDs and a trimerization core have been determined, the structure of the full length of RPA or the RPA-ssDNA complex remains unknown. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17583916
DOI: 10.1021/bi7004976
PMCID: PMC2553558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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