Integrated phospho-proteogenomic and single-cell transcriptomic analysis of meningiomas establishes robust subtyping and reveals subtype-specific immune invasion

Abstract excerpt

<h4>ABSTRACT</h4> Meningiomas are the most frequent primary intracranial tumors. They can follow a wide clinical spectrum from benign to highly aggressive clinical course. No specific therapy exists for refractory cases or cases not amenable to resection and radiotherapy. Identification of risk of recurrence and malignant transformation for the individual patients is challenging. However, promising molecular mark...

Topics

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• Data Analysis
• DNA Methylation
• Drug Discovery
• Meningioma
• Proteogenomics
• Reproducibility of Results
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

04e0481e-6c35-5a8c-a570-f643a3099414

DOI

10.1101/2021.05.11.443369