Article
Whole-genome sequencing identifies new genetic alterations in meningiomas.
Oncotarget - 7 Mar 2017
Tang Mei, Wei Heng, Han Lu, Deng Jiaojiao, Wang Yuelong, Yang Meijia, Tang Yani, Guo Gang, Zhou Liangxue, Tong Aiping
Abstract excerpt
The major known genetic contributor to meningioma formation was NF2, which is disrupted by mutation or loss in about 50% of tumors. Besides NF2, several recurrent driver mutations were recently uncovered through next-generation sequencing. Here, we performed whole-genome sequencing across 7 tumor-normal pairs to identify somatic genetic alterations in meningioma. As a result, Chromatin regulators, including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.