Article

PTEN deficiency linked to chromosome 10q loss leads to aggressive NF2 mutant meningioma biology

2025-12-22

Abstract excerpt

While most meningiomas are benign and can be surgically removed, a subset behaves aggressively, recurs quickly, and can ultimately be fatal. Recent work has focused on defining this aggressive group. To better characterize this clinically distinct, high-risk group, we analyzed bulk RNA sequencing (RNA-seq) from human meningiomas using a dimension-reduced reference landscape. We identified an NF2 mutant subtype enr...

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Literature Corpus work: 63d5c6c2-9146-529c-8995-9b6de7083eca
DOI: 10.64898/2025.12.21.695820

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