Article
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.
Nature genetics - 1 Jan 2024
Caswell Deborah R, Gui Philippe, Mayekar Manasi K, Law Emily K, Pich Oriol, Bailey Chris, Boumelha Jesse, Kerr D Lucas, Blakely Collin M, Manabe Tadashi, Martinez-Ruiz Carlos, Bakker Bjorn, De Dios Palomino Villcas Juan, I Vokes Natalie, Dietzen Michelle, Angelova Mihaela, Gini Beatrice, Tamaki Whitney, Allegakoen Paul, Wu Wei, Humpton Timothy J, Hill William, Tomaschko Mona, Lu Wei-Ting, Haderk Franziska, Al Bakir Maise, Nagano Ai, Gimeno-Valiente Francisco, de Carné Trécesson Sophie, Vendramin Roberto, Barbè Vittorio, Mugabo Miriam, Weeden Clare E, Rowan Andrew, McCoach Caroline E, Almeida Bruna, Green Mary, Gomez Carlos, Nanjo Shigeki, Barbosa Dora, Moore Chris, Przewrocka Joanna, Black James R M, Grönroos Eva, Suarez-Bonnet Alejandro, Priestnall Simon L, Zverev Caroline, Lighterness Scott, Cormack James, Olivas Victor, Cech Lauren, Andrews Trisha, Rule Brandon, Jiao Yuwei, Zhang Xinzhu, Ashford Paul, Durfee Cameron, Venkatesan Subramanian, Temiz Nuri Alpay, Tan Lisa, Larson Lindsay K, Argyris Prokopios P, Brown William L, Yu Elizabeth A, Rotow Julia K, Guha Udayan, Roper Nitin, Yu Johnny, Vogel Rachel I, Thomas Nicholas J, Marra Antonio, Selenica Pier, Yu Helena, Bakhoum Samuel F, Chew Su Kit, Reis-Filho Jorge S, Jamal-Hanjani Mariam, Vousden Karen H, McGranahan Nicholas, Van Allen Eliezer M, Kanu Nnennaya, Harris Reuben S, Downward Julian, Bivona Trever G, Swanton Charles
Abstract excerpt
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant (EGFRmut) non-small-cell lung cancer (NSCLC) mouse models constrained tumorigenesis, while A3B expression in tumors treated with EGFR-targeted cancer therapy was associated with treatment...
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