Article

APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC mutagenesis is one of the most common endogenous sources of mutations in human cancer and is a major source of genetic intratumor heterogeneity. High levels of APOBEC mutagenesis are associated with poor prognosis and aggressive disease across diverse cancers, but the mechanistic and functional impacts of APOBEC mutagenesis on tumor evolution and therapy resistance remain relatively unexp...

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Literature Corpus work: 01dfd37b-134d-50c2-a42a-0424989377c4
DOI: 10.1101/2023.07.02.547443

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