Article

Contribution of rare coding variants to complex trait heritability

2022-11-22

Abstract excerpt

<title>Abstract</title> <p>It has been postulated that rare coding variants (RVs; MAF<0.01) contribute to the “missing” heritability of complex traits. We developed a novel framework, the Rare variant heritability (RARity) estimator, to assess RV heritability (h2RV) without assuming a particular genetic architecture. We applied RARity to 31 complex traits in the UK Biobank (N=167,348) and showed that gene-level R...

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Literature Corpus work: 5aeff041-7bf9-50e6-be33-082cb2f8f5d2
DOI: 10.21203/rs.3.rs-2159360/v1

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