Article

Saturation genome editing of <i>BRCA1</i> across cell types accurately resolves cancer risk

2025-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Germline pathogenic BRCA1 variants predispose women to breast and ovarian cancer. Despite accumulation of functional evidence for variants in BRCA1 , over half of reported single-nucleotide variants (SNVs) lack a definitive clinical interpretation. Furthermore, the extent to which variant effects are consistent across cell types remains largely unexplored. Here, we performed saturation genome...

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Literature Corpus work: 2b4e2a77-eac1-5e76-b120-24787b30fad0
DOI: 10.1101/2025.08.11.25333423

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