Article

REFCON: Reference-free and robust copy number inference in single-cell tumor transcriptomes

2026-08-07

Abstract excerpt

Abstract Single-cell RNA sequencing (scRNA-seq) is widely used to infer copy number profiles from tumor cells. Existing methods build on a reference-based normalization paradigm: normalizing each tumor cell against a reference of normal cells, whether supplied, in-sample, or synthesized. This makes them reference-dependent and as a result, sensitive to cohort composition, and prone to false positives. To address t...

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Literature Corpus work: 44a80c3b-1331-5414-ab32-efb0efd0f7ed
DOI: 10.64898/2026.08.03.742406

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