Article

Learning copy number dependent variation in single tumour cell transcriptomes with deep generative models

2025-04-25

Abstract excerpt

Large-scale copy number aberrations are a hallmark of many cancers, showing widespread associations with tumour cell phenotypes, therapy resistance, and patient outcomes. Several existing methods can infer copy number profiles from single-cell RNA-sequencing data. However, there is currently no methodology to separate the effects of the copy number state on single tumour cell phenotypes from the copy number-indepe...

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Literature Corpus work: ed177890-513b-5f60-8fda-0e88bd29d0cf
DOI: 10.1101/2025.04.21.649842

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