Article

DRP1-mediated mitochondrial fission integrates growth hormone signaling with metabolic and stress adaptation in triple-negative breast cancer

2026-03-10

Abstract excerpt

Triple-negative breast cancer (TNBC) relies on metabolic plasticity to sustain growth under diverse microenvironmental conditions. Although growth hormone (GH) signaling has been linked to breast cancer progression, its mechanistic integration with mitochondrial dynamics and metabolic reprogramming remains unclear. Here, we show that GH promotes TNBC progression accompanied by DRP1-associated mitochondrial remodel...

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Literature Corpus work: 447503b6-91ac-5c5d-a8fe-6ee7b6dafefd
DOI: 10.64898/2026.03.08.710368

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