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Article

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.

Cells - 31 May 2021

Morein Dina, Rubinstein-Achiasaf Linor, Brayer Hadar, Dorot Orly, Pichinuk Edward, Ben-Yaakov Hagar, Meshel Tsipi, Pasmanik-Chor Metsada, Ben-Baruch Adit

Abstract excerpt

Chronic inflammation promotes cancer progression by affecting the tumor cells and their microenvironment. Here, we demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype. While not...

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Source

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Identifiers

PMID: 34072893
DOI: 10.3390/cells10061356
PMCID: PMC8229065

Genes

CCL2
CXCL1
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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