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Heterogeneity and transcriptional drivers of triple-negative breast cancer

1 Dec 2023

Abstract excerpt

Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity, we defined transcriptional, epigenetic, and metabolic subtypes and subtype-driving super-enhancers and transcription factors by combining functional and molecular profiling with computational analyses. Single-cell RNA sequencing revealed relative homogeneity of the major...

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PMID: 38100350
DOI: 10.1016/j.celrep.2023.113564

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