Article

RBBP4 orchestrates glycolytic reprogramming and NF-κB-mediated immune evasion in triple-negative breast cancer

2025-08-17

Abstract excerpt

<title>Abstract</title> <p><bold>Objective: </bold>To investigate the role of retinoblastoma binding protein 4 (RBBP4) in triple-negative breast cancer (TNBC), an aggressive tumor lacking targeted treatments, and explore its potential as a therapeutic target. <bold>Methods: </bold>The study analyzed RBBP4 expression in TNBC tumors and its association with patient survival. Experimental approaches included assessi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e3585f1-298e-5117-9ab8-5ac80444ea35
DOI: 10.21203/rs.3.rs-7280626/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RBBP4 orchestrates glycolytic reprogramming and NF-κB-mediated immune evasion in triple-negative breast cancerDOI 10.21203/rs.3.rs-7280626/v1Read

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast CancerSemantic proximity Read

Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast CancerSemantic proximity Read

miR-526b dysregulates glucose metabolism via the COX2/EP4 pathwaySemantic proximity Read

MYC-Driven Pathways in Breast Cancer SubtypesSemantic proximity Read

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1αSemantic proximity Read

DRP1-mediated mitochondrial fission integrates growth hormone signaling with metabolic and stress adaptation in triple-negative breast cancerSemantic proximity Read

A lactate‐responsive gene signature predicts the prognosis and immunotherapeutic response of patients with triple‐negative breast cancerSemantic proximity Read

GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast CancerSemantic proximity Read

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast CancerSemantic proximity Read

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibitionSemantic proximity Read

Identification of Lactate-Related Subgroups and Prognostic Model in Triple-Negative Breast CancerSemantic proximity Read

KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylationSemantic proximity Read