Article

ATM functions as a rheostat of metabolic stress in small-cell lung cancer

2026-03-17

Abstract excerpt

ATM is best known as a guardian of genomic stability, yet its contributions to oncogenic signaling in aggressive malignancies like small-cell lung cancer (SCLC) remain poorly understood. Despite ATM being an established clinical vulnerability in SCLC, its influence on dysregulated tumorigenic circuits remains unclear. We demonstrate that inhibition of ATM disrupts the AKT-mTORC1-4EBP1 signaling axis, leading to at...

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Literature Corpus work: cb435d05-474f-5a4b-a7d2-0730e979ce42
DOI: 10.64898/2026.03.13.711672

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