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Article

SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.

Cancer research - 2 Jul 2025

Sen Utsav, Coleman Charles, Gandhi Nishant, Jethalia Vrinda, Demircioglu Deniz, Elliott Andrew, Vanderwalde Ari M, Hayatt Omar, de Stanchina Elisa, Halmos Balazs, Ma Patrick C, Berisa Mirela, Hasson Dan, Sen Triparna

Abstract excerpt

Concurrent inactivating mutations in STK11 and KEAP1 drive primary resistance to therapies, leading to worse outcomes in KRAS-mutated lung adenocarcinoma (KRASmut LUAD), and are associated with metabolic alterations. Elucidation of the underlying biology of this aggressive LUAD subset is needed to develop effective treatments to improve patient outcomes. Our transcriptomic analysis of 5,498 "real-world" KRASmut...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kelch-Like ECH-Associated Protein 1

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Source

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Identifiers

PMID: 40198901
DOI: 10.1158/0008-5472.CAN-24-2745
PMCID: PMC12221774

Genes

SLC7A11
KEAP1
STK11
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.PMID 40198901Read ↗

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.Semantic proximity Read ↗

Targeting <i>de novo</i> lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancerSemantic proximity Read ↗

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer.Semantic proximity Read ↗

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.Semantic proximity Read ↗

Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosisSemantic proximity Read ↗

High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinomaSemantic proximity Read ↗

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia.Semantic proximity Read ↗

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancerSemantic proximity Read ↗

Therapeutic strategies of metabolic reprogramming in non-small cell lung carcinoma.Semantic proximity Read ↗

EGFR Mutation Subtypes Modulate Distinct Metabolic Profiles and Clinical Outcomes in Lung Cancer: A Retrospective AnalysisSemantic proximity Read ↗

Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancerSemantic proximity Read ↗

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status.Semantic proximity Read ↗

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