Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accelerated aging in the tumor microenvironment

1 Jul 2011

Abstract excerpt

Cancer is thought to be a disease associated with aging. Interestingly, normal aging is driven by the production of ROS and mitochondrial oxidative stress, resulting in the cumulative accumulation of DNA damage. Here, we discuss how ROS signaling, NFκB- and HIF1-activation in the tumor microenvironment induces a form of "accelerated aging," which leads to stromal inflammation and changes in cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Caveolin-1 and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21654190
DOI: 10.4161/cc.10.13.16233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accelerated aging in the tumor microenvironmentPMID 21654190Read ↗

Understanding the "lethal" drivers of tumor-stroma co-evolutionSemantic proximity Read ↗

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolismSemantic proximity Read ↗

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironmentSemantic proximity Read ↗

Metabolic reprogramming: a bridge between aging and tumorigenesisSemantic proximity Read ↗

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis <i>via</i> Oxidative Stress, Mitophagy, and Aerobic GlycolysisSemantic proximity Read ↗

Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted ParadoxSemantic proximity Read ↗

Autophagic tumor stroma: Mechanisms and roles in tumor growth and progressionSemantic proximity Read ↗

Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery.Semantic proximity Read ↗

Cancer and aging: a model for the cancer promoting effects of the aging stroma.Semantic proximity Read ↗

Interplay between ROS and Autophagy in Cancer and Aging: From Molecular Mechanisms to Novel Therapeutic ApproachesSemantic proximity Read ↗

Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: A model for solid‐cancer initiation and early developmentSemantic proximity Read ↗

Metabolic, autophagic, and mitophagic activities in cancer initiation and progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.