Article

Dietary α-Ketoglutarate delays lung adenocarcinoma in females and modulates TBX5-associated transcriptional programs and the immune microenvironment

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Lung adenocarcinoma (LUAD) is the most common form of lung cancer and a leading cause of cancer-related mortality, underscoring the need for new chemopreventive strategies. α-Ketoglutarate (α-KG), a tricarboxylic acid cycle metabolite and dioxygenase cofactor, links cellular metabolism to chromatin regulation. Here, we show that dietary α-KG remodels LUAD in a sex-dependent manner. In female mic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22c616ee-b8fc-53d6-85a1-365a0c2f3d29
DOI: 10.1101/2025.09.19.677388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dietary α-Ketoglutarate delays lung adenocarcinoma in females and modulates TBX5-associated transcriptional programs and the immune microenvironmentDOI 10.1101/2025.09.19.677388Read

Aging promotes lung cancer metastasis through epigenetic ATF4 inductionSemantic proximity Read

Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinomaSemantic proximity Read

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cellsSemantic proximity Read

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumorsSemantic proximity Read

Mitochondrial metabolism as a potential novel therapeutic target for lung adenocarcinomaSemantic proximity Read

Super-enhancer impairment is a link between MLL4-inactivated lung tumors and their vulnerability to glycolysis pathway inhibitionSemantic proximity Read

Immunity Depletion, Telomere Imbalance, and Cancer-associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Caloric RestrictionSemantic proximity Read

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy ResponseSemantic proximity Read

SYVN1-mediated ubiquitylation directs the localization of MCT4 in plasma membrane to promote the progression of lung adenocarcinomaSemantic proximity Read

<i>Acidovorax temperans</i> polarizes T17 cells and skews neutrophil maturation to promote lung adenocarcinoma developmentSemantic proximity Read

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.Semantic proximity Read

Oncometabolite D-2-hydroxyglutarate - dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexiaSemantic proximity Read