Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.

doi:10.1016/0925-4439(95)00026-z

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Article

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.

Biochimica et biophysica acta - 24 May 1995

Ozawa T

Abstract excerpt

Mitochondrial DNA (mtDNA) that codes protein subunits essential for the maintenance of mitochondrial ATP synthesis system acquires mutations at a much higher rate than that in nuclear DNA. Recent study has revealed that somatically acquired mutations such as deletions in mtDNA are caused mainly by oxygen free-radical damage. Cumulative accumulation of these somatic mutations during the life of an individual...

Topics

Aging
Amino Acid Sequence
Animals
Base Sequence
Cardiomyopathies
Cytochrome b Group
DNA, Mitochondrial
Female
Humans
Male
Mitochondria, Muscle
Mitochondrial Myopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Parkinson Disease

Point Mutation

Polymerase Chain Reaction

Proton-Translocating ATPases

Source

Open in PubMed

Identifiers

PMID: 7599206
DOI: 10.1016/0925-4439(95)00026-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7599206-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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