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Article

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.

Biochimica et biophysica acta - 24 May 1995

Ozawa T

Abstract excerpt

Mitochondrial DNA (mtDNA) that codes protein subunits essential for the maintenance of mitochondrial ATP synthesis system acquires mutations at a much higher rate than that in nuclear DNA. Recent study has revealed that somatically acquired mutations such as deletions in mtDNA are caused mainly by oxygen free-radical damage. Cumulative accumulation of these somatic mutations during the life of an individual...

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PMID: 7599206
DOI: 10.1016/0925-4439(95)00026-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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