Article
Human male infertility caused by mutations in the CATSPER1 channel protein.
American journal of human genetics - 1 Apr 2009
Avenarius Matthew R, Hildebrand Michael S, Zhang Yuzhou, Meyer Nicole C, Smith Luke L H, Kahrizi Kimia, Najmabadi Hossein, Smith Richard J H
Abstract excerpt
Male infertility, a common barrier that prevents successful conception, is a reproductive difficulty affecting 15% of couples. Heritable forms of nonsyndromic male infertility can arise from single-gene defects as well as chromosomal abnormalities. Although no CATSPER gene has been identified as causative for human male infertility, male mice deficient for members of the CatSper gene family are infertile. In this...
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