Article
Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.
Oncogene - 17 Jul 2014
Liu J, Visser-Grieve S, Boudreau J, Yeung B, Lo S, Chamberlain G, Yu F, Sun T, Papanicolaou T, Lam A, Yang X, Chin-Sang I
Abstract excerpt
Insulin and insulin-like growth factor-1 signaling have fundamental roles in energy metabolism, growth and development. Recent research suggests hyperactive insulin receptor (IR) and hyperinsulinemia are cancer risk factors. However, the mechanisms that account for the link between the hyperactive insulin signaling and cancer risk are not well understood. Here we show that an insulin-like signaling inhibits the...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Line
- Gene Expression
- Humans
- Insulin
- Insulins
- Intestinal Mucosa
- Models, Biological
- Mutation
- Neurons