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Article

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Gil E B, Malone Link E, Liu L X, Johnson C D, Lees J A

Abstract excerpt

The human PTEN tumor suppressor gene is mutated in a wide variety of sporadic tumors. To determine the function of PTEN in vivo we have studied a PTEN homolog in Caenorhabditis elegans. We have generated a strong loss-of-function allele of the PTEN homolog and shown that the deficient strain is u...

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Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 10077613
DOI: 10.1073/pnas.96.6.2925
PMCID: PMC15871

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10077613-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.PMID 10077613Read ↗

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