Article
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
Molecular cell - 1 Dec 1998
Ogg S, Ruvkun G
Abstract excerpt
An insulin-like signaling pathway, from the DAF-2 receptor, the AGE-1 phosphoinositide 3-kinase, and the AKT-1/AKT-2 serine/threonine kinases to the DAF-16 Fork head transcription factor, regulates the metabolism, development, and life span of Caenorhabditis elegans. Inhibition of daf-18 gene act...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Epistasis, Genetic
- Gene Expression Regulation
- Genes, Helminth
- Helminth Proteins
- Larva
- Molecular Sequence Data
- PTEN Phosphohydrolase
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphoric Monoester Hydrolases
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt