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Article

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Molecular cell - 1 Dec 1998

Ogg S, Ruvkun G

Abstract excerpt

An insulin-like signaling pathway, from the DAF-2 receptor, the AGE-1 phosphoinositide 3-kinase, and the AKT-1/AKT-2 serine/threonine kinases to the DAF-16 Fork head transcription factor, regulates the metabolism, development, and life span of Caenorhabditis elegans. Inhibition of daf-18 gene activity bypasses the normal requirement for AGE-1 and partially bypasses the need for DAF-2 signaling. The suppression of...

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Source

Identifiers

PMID: 9885576
DOI: 10.1016/s1097-2765(00)80303-2

Genes

PTEN
TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.PMID 9885576Read ↗

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.Semantic proximity Read ↗

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.Semantic proximity Read ↗

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.Semantic proximity Read ↗

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.Semantic proximity Read ↗

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.Semantic proximity Read ↗

Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.Semantic proximity Read ↗

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.Semantic proximity Read ↗

The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16Semantic proximity Read ↗

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.Semantic proximity Read ↗

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceSemantic proximity Read ↗

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.Semantic proximity Read ↗

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.Semantic proximity Read ↗

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