Article

Increased ABCA1 activity protects against atherosclerosis

2002-07-01

Abstract excerpt

The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages. Previously, it was demonstrated that human ABCA1 overexpression in vivo in transgenic mice results in a mild elevation of plasma HDL levels and increased efflux of cholesterol from macrophages. In this study, we determined the effect of overexpression of ABCA1 on at...

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Literature Corpus work: 44169020-ef17-52a8-a6e8-3460a654a88c
DOI: 10.1172/jci0215748

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