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Article

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.

Journal of lipid research - 1 Nov 2001

Attie A D, Kastelein J P, Hayden M R

Abstract excerpt

The identification of mutations in ABCA1 in patients with Tangier disease and familial HDL deficiency demonstrated that inadequate transport of phospholipid and cholesterol to the extracellular space results in the hypercatabolism of lipid-poor nascent HDL particles. However, the relationship bet...

Read the complete abstract on PubMed

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Share to Arteriosclerosis
Share to ATP Binding Cassette Transporter 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport

Share to Cholesterol

Share to Chromosomes, Artificial, Bacterial

Share to Coronary Disease

Share to Lipoproteins, HDL

Source

Identifiers

PMID: 11714841

Genes

ABCA1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11714841-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.PMID 11714841Read ↗

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Increased ABCA1 activity protects against atherosclerosisSemantic proximity Read ↗

ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Semantic proximity Read ↗

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ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?Semantic proximity Read ↗

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.Semantic proximity Read ↗

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