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Article

Study of ABCA1 Function in Transgenic Mice

1 Jun 2003

Abstract excerpt

The ATP-binding cassette transporter A1 (ABCA1), identified in 1999 as the gene defective in Tangier disease, promotes efflux of cellular cholesterol from macrophages and other peripheral tissues to apolipoprotein acceptors. These ABCA1-mediated processes are anticipated to have antiatherogenic properties, prompting the development of pharmacological agents that increase ABCA1 gene expression as well as the...

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PMID: 12615681
DOI: 10.1161/01.atv.0000055194.85073.ff

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