Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000

McNeish J, Aiello R J, Guyot D, Turi T, Gabel C, Aldinger C, Hoppe K L, Roach M L, Royer L J, de Wet J, Broccardo C, Chimini G, Francone O L

Abstract excerpt

Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been demonstrated to be mutated in patients with Tangier disease. To investigate the role of the ABC1 protein in an experimental in vivo model, we used gene targeting in DBA-1J embryonic stem cells to produce an ABC1-deficient mouse. Expression of the murine Abc1 gene was ablated by using a nonisogenic targeting construct that deletes six...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter 1
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol

Share to DNA Primers

Share to Foam Cells

Share to Glycoproteins

Share to Lipoproteins, HDL

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 10760292
DOI: 10.1073/pnas.97.8.4245
PMCID: PMC18215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.PMID 10760292Read ↗

Study of ABCA1 Function in Transgenic MiceSemantic proximity Read ↗

Tangier disease and ABCA1.Semantic proximity Read ↗

ATP binding cassette transporter A1--key roles in cellular lipid transport and atherosclerosis.Semantic proximity Read ↗

ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation.Semantic proximity Read ↗

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.Semantic proximity Read ↗

ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?Semantic proximity Read ↗

Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice.Semantic proximity Read ↗

Human ATP-binding cassette transporter 1 (ABC1): Genomic organization and identification of the genetic defect in the original Tangier disease kindredSemantic proximity Read ↗

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency.Semantic proximity Read ↗

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1.Semantic proximity Read ↗

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway.Semantic proximity Read ↗

ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.