Article
Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016
Westerterp Marit, Tsuchiya Kyoichiro, Tattersall Ian W, Fotakis Panagiotis, Bochem Andrea E, Molusky Matthew M, Ntonga Vusisizwe, Abramowicz Sandra, Parks John S, Welch Carrie L, Kitajewski Jan, Accili Domenico, Tall Alan R
Abstract excerpt
OBJECTIVE: Plasma high-density lipoproteins have several putative antiatherogenic effects, including preservation of endothelial functions. This is thought to be mediated, in part, by the ability of high-density lipoproteins to promote cholesterol efflux from endothelial cells (ECs). The ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) interact with high-density lipoproteins to promote cholesterol...
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