Article
Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
van Eck Miranda, Bos I Sophie T, Kaminski Wolfgang E, Orsó Evelyn, Rothe Gregor, Twisk Jaap, Böttcher Alfred, Van Amersfoort Edwin S, Christiansen-Weber Trudy A, Fung-Leung Wai-Ping, Van Berkel Theo J C, Schmitz Gerd
Abstract excerpt
The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a key regulator of high-density lipoprotein (HDL) metabolism, which is defective in familial HDL-deficiency syndromes such as Tangier disease. ABCA1 functions as a facilitator of cellular cholesterol and phospholipid efflux, and its expression is induced during cholesterol uptake in macrophages. To assess the role of macrophage ABCA1...
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