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Article

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

van Eck Miranda, Bos I Sophie T, Kaminski Wolfgang E, Orsó Evelyn, Rothe Gregor, Twisk Jaap, Böttcher Alfred, Van Amersfoort Edwin S, Christiansen-Weber Trudy A, Fung-Leung Wai-Ping, Van Berkel Theo J C, Schmitz Gerd

Abstract excerpt

The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a key regulator of high-density lipoprotein (HDL) metabolism, which is defective in familial HDL-deficiency syndromes such as Tangier disease. ABCA1 functions as a facilitator of cellular cholesterol and phospholipid e...

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Source

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Identifiers

PMID: 11972062
DOI: 10.1073/pnas.092327399
PMCID: PMC122943

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11972062-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.PMID 11972062Read ↗

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Tangier disease and ABCA1.Semantic proximity Read ↗

ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Semantic proximity Read ↗

Increased ABCA1 activity protects against atherosclerosisSemantic proximity Read ↗

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.Semantic proximity Read ↗

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.Semantic proximity Read ↗

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.Semantic proximity Read ↗

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.Semantic proximity Read ↗

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