Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms.

Nature - 10 Jul 2014

Potenski Catherine J, Niu Hengyao, Sung Patrick, Klein Hannah L

Abstract excerpt

Srs2 helicase is known to dismantle nucleofilaments of Rad51 recombinase to prevent spurious recombination events and unwind trinucleotide sequences that are prone to hairpin formation. Here we document a new, unexpected genome maintenance role of Srs2 in the suppression of mutations arising from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomic Instability
Share to Ribonuclease H
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Exodeoxyribonucleases

Share to Ribonucleotides

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24896181
DOI: 10.1038/nature13292
PMCID: PMC4140095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24896181-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms.PMID 24896181Read ↗

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescueSemantic proximity Read ↗

Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phaseSemantic proximity Read ↗

Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats.Semantic proximity Read ↗

RNase H2 roles in genome integrity revealed by unlinking its activities.Semantic proximity Read ↗

DNA2 drives processing and restart of reversed replication forks in human cellsSemantic proximity Read ↗

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integritySemantic proximity Read ↗

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Semantic proximity Read ↗

Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Semantic proximity Read ↗

A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response in human cellsSemantic proximity Read ↗

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.Semantic proximity Read ↗

Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.