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Homology-directed repair protects the replicating genome from metabolic assaults.

Developmental cell - 22 Feb 2021

Somyajit Kumar, Spies Julian, Coscia Fabian, Kirik Ufuk, Rask Maj-Britt, Lee Ji-Hoon, Neelsen Kai John, Mund Andreas, Jensen Lars Juhl, Paull Tanya T, Mann Matthias, Lukas Jiri

Abstract excerpt

Homology-directed repair (HDR) safeguards DNA integrity under various forms of stress, but how HDR protects replicating genomes under extensive metabolic alterations remains unclear. Here, we report that besides stalling replication forks, inhibition of ribonucleotide reductase (RNR) triggers metabolic imbalance manifested by the accumulation of increased reactive oxygen species (ROS) in cell nuclei. This leads...

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Identifiers

PMID: 33621493
DOI: 10.1016/j.devcel.2021.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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