Article

BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments

2025-05-19

Abstract excerpt

CRISPR base editors enable scalable targeted DNA mutagenesis and are a powerful tool for the interpretation of gene function, the study of variants of unknown significance, and disease modelling. Existing guide RNA (gRNA) design tools focus on engineering a small number of targeted variants in a given gene or lack comprehensive functional annotation of target sequences. Here we developed BEstimate, a flexible comp...

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Literature Corpus work: 43db1dfa-569d-5ae6-b65f-3ccbaae75ae3
DOI: 10.1101/2025.05.19.654892

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