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Article

Valve interstitial cell shape modulates cell contractility independent of cell phenotype.

Journal of biomechanics - 3 Oct 2016

Tandon Ishita, Razavi Atefeh, Ravishankar Prashanth, Walker Addison, Sturdivant Nasya M, Lam Ngoc Thien, Wolchok Jeffrey C, Balachandran Kartik

Abstract excerpt

Valve interstitial cells are dispersed throughout the heart valve and play an important role in maintaining its integrity, function, and phenotype. While prior studies have detailed the role of external mechanical and biological factors in the function of the interstitial cell, the role of cell shape in regulating contractile function, in the context of normal and diseased phenotypes, is not well understood....

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Identifiers

PMID: 27567567
DOI: 10.1016/j.jbiomech.2016.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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