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Article

Soft Substrate Culture to Mechanically Control Cardiac Myofibroblast Activation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Landry Natalie M, Rattan Sunil G, Dixon Ian M C

Abstract excerpt

Two-dimensional cell culture is the primary method employed for proof-of-concept studies in most molecular biology labs. While immortalized cell lines are convenient and easy to maintain for extended periods in vitro, their inability to accurately represent genuine cell physiology-or pathophysiology-presents a challenge for drug discovery, as most results are not viable for the transition to clinical trial. The...

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Source

Identifiers

PMID: 34028743
DOI: 10.1007/978-1-0716-1382-5_13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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