Article

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis

2020-07-06

Abstract excerpt

Technological advancements have enabled the design of increasingly complex engineered tissue constructs, which better mimic native tissue cellularity. Therefore, dissecting the bi-directional interactions between distinct cell types in 3D is necessary to understand how heterotypic interactions at the single-cell level impact tissue-level properties. We systematically interrogated the interactions between cardiomyo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d144af7-e34a-5ebb-a87e-4dd81daad345
DOI: 10.1101/2020.07.06.190504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional AnalysisDOI 10.1101/2020.07.06.190504Read

Cell-cell interactions in the heart: advanced cardiac models and omics technologiesSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodelingSemantic proximity Read

Progressive developmental cues from multiple cardiac cell types promote cardiomyocyte maturationSemantic proximity Read

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblastsSemantic proximity Read

3D Cardiac Microtissues Encapsulated with the Co‐Culture of Cardiomyocytes and Cardiac FibroblastsSemantic proximity Read

Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heartSemantic proximity Read

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart DiseaseSemantic proximity Read

Designing multicellular cardiac tissue engineering technologies for clinical translationSemantic proximity Read

Tissue microenvironment dictates the state of human induced pluripotent stem cell-derived endothelial cells of distinct developmental origin in 3D cardiac microtissuesSemantic proximity Read

Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult MyocardiumSemantic proximity Read

Human left ventricular cardiac fibroblasts undergo a dynamic shift in secretome and gene expression toward a cardiac myofibroblast phenotype during early passage in typical culture expansion conditions.Semantic proximity Read