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Article

Substrate stiffness modulates gene expression and phenotype in neonatal cardiomyocytes in vitro.

Tissue engineering. Part A - 1 Sept 2012

Forte Giancarlo, Pagliari Stefania, Ebara Mitsuhiro, Uto Koichiro, Tam Janice Kal Van, Romanazzo Sara, Escobedo-Lucea Carmen, Romano Elena, Di Nardo Paolo, Traversa Enrico, Aoyagi Takao

Abstract excerpt

Biomaterials to be used as cell delivery systems for cardiac tissue engineering should be able to comply with cardiac muscle contractile activity, while favoring cell survival and neo-angiogenesis in a hostile environment. Biocompatible synthetic materials can be tailored to mimic cardiac tissue three-dimensional organization in the micro- and nanoscales. Nonetheless, they usually display mechanical properties...

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Identifiers

PMID: 22519549
DOI: 10.1089/ten.TEA.2011.0707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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